Track 29: Genetic and Molecular Dermatology

Genetic and Molecular Dermatology

Genetic and molecular dermatology represents a rapidly advancing frontier in skin research and clinical medicine, focusing on the genetic, epigenetic, and molecular mechanisms that underpin skin development, function, and disease. By unraveling the complex interplay between genes, proteins, and signaling pathways, this field has significantly deepened our understanding of both inherited and acquired dermatologic disorders, paving the way for precision diagnostics and targeted therapies.

A wide spectrum of skin diseases—including genodermatoses, epidermolysis bullosa, ichthyoses, albinism, and various connective tissue disorders—arise from genetic mutations that disrupt key structural or regulatory components of the skin. Advances in genomic technologies, such as next-generation sequencing (NGS), whole-exome sequencing, and CRISPR-based gene editing, have revolutionized the identification of pathogenic variants and disease mechanisms. These breakthroughs have enabled earlier diagnosis, refined disease classification, and informed personalized treatment strategies.

Molecular dermatology extends beyond rare genetic conditions to encompass common disorders such as psoriasis, atopic dermatitis, and skin cancers, where gene-environment interactions and immune dysregulation play crucial roles. Studies of molecular signaling pathways—including MAPK, JAK-STAT, and Wnt—have provided critical insights into skin homeostasis, inflammation, and tumorigenesis, driving the development of biologic agents and small-molecule inhibitors that precisely target these pathways.

Emerging research in epigenetics, non-coding RNAs, and proteomics continues to uncover novel mechanisms influencing skin disease expression and therapeutic response. Regenerative medicine and gene therapy approaches—such as RNA-based therapeutics, stem cell reprogramming, and in vivo gene correction—are poised to redefine the future of dermatologic treatment, offering potential cures for previously untreatable genetic disorders.

The session on Genetic and Molecular Dermatology will bring together geneticists, molecular biologists, dermatologists, and translational researchers to explore the latest advances in skin genomics, molecular diagnostics, and targeted therapies. Participants will gain in-depth insights into cutting-edge technologies, precision medicine applications, and future directions that are transforming our understanding and management of genetically and molecularly driven skin diseases.